A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest

Phytother Res. 2010 Oct;24(10):1447-50. doi: 10.1002/ptr.3153.

Abstract

A new arabinopyranoside was isolated from the alga Laurencia majuscula (Harvey) Lucas, collected from the Xisha Islands in the South China Sea. Its structure was elucidated as hexadecyl-1-O-α-L-arabinopyranoside by spectroscopic analysis. It was found that arabinopyranoside had significant antitumor activity in LOVO and Bel-7402 cell lines. Flow cytometric analysis showed that arabinopyranoside arrested the cell cycle in the G2/M phase. Western blotting demonstrated that the protein expression of CDK1 and cyclin A related to the G2/M phase decreased markedly with arabinopyranoside treatment, with slight changes in cyclin B1 expression. Taken together, the findings identify a potential new antitumor therapeutic arabinopyranoside isolated from red alga Laurencia majuscula.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Cycle / drug effects*
  • Cell Line, Tumor
  • Glycolipids / isolation & purification*
  • Glycolipids / pharmacology
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Humans
  • Laurencia / chemistry*
  • Molecular Structure

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycolipids
  • Glycosides
  • hexadecyl-1-O-arabinopyranoside