Pulmonary hypertension associated with use of phentermine

Yonsei Med J. 2010 Nov;51(6):971-3. doi: 10.3349/ymj.2010.51.6..


Weight-control drugs (known as anorexigens) such as fenfluramine have been linked with pulmonary hypertension in previous reports. In our case, a 29 year old woman was admitted for shortness of breath and was diagnosed with pulmonary hypertension. Three months ago, she had been taking phentermine for five weeks. Other factors that might have contributed to the development of pulmonary hypertension were excluded. With treatment, her symptoms improved. This is the first case that can suggest a possible connection between phenermine single medication with pulmonary hypertension. Phentermine has been considered a relatively safe drug to treat obesity, and further investigation is needed to decide the safety and dosage of phentermine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use
  • Bosentan
  • Electrocardiography / methods
  • Female
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / etiology*
  • Models, Chemical
  • Obesity / drug therapy
  • Phentermine / adverse effects*
  • Phentermine / therapeutic use*
  • Radiography, Thoracic / methods
  • Safety
  • Sulfonamides / therapeutic use


  • Antihypertensive Agents
  • Sulfonamides
  • Phentermine
  • Bosentan