The devastating earthquake in Haiti on January 12, 2010, resulted in massive destruction and human suffering that captured attention worldwide. This column details the experiences shared by the anesthesia department aboard the USNS Comfort. A total of 843 urgent and emergent surgical cases were completed. The mission included cooperation of both military and civilian anesthesia providers. The level of devastation and trauma provided an experience unparalleled by most trauma units and will forever be etched in the minds of those who responded.