First report on fertility after allogeneic uterus transplantation

Acta Obstet Gynecol Scand. 2010 Nov;89(11):1491-4. doi: 10.3109/00016349.2010.520688. Epub 2010 Sep 30.

Abstract

Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Fertility
  • Graft Rejection / prevention & control
  • Immunosuppressive Agents / pharmacology
  • Infertility, Female / therapy*
  • Male
  • Pregnancy
  • Rats
  • Rats, Inbred Lew
  • Rats, Sprague-Dawley
  • Tacrolimus / pharmacology
  • Transplantation, Homologous
  • Uterus / transplantation*

Substances

  • Immunosuppressive Agents
  • Tacrolimus