Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Dec;15(8):E177-82.
doi: 10.1111/j.1399-3046.2010.01365.x. Epub 2010 Sep 30.

Platelet Transfusion Refractoriness Attributable to HLA Antibodies Produced by Donor-Derived Cells After Allogeneic Bone Marrow Transplantation From One HLA-antigen-mismatched Mother

Affiliations
Case Reports

Platelet Transfusion Refractoriness Attributable to HLA Antibodies Produced by Donor-Derived Cells After Allogeneic Bone Marrow Transplantation From One HLA-antigen-mismatched Mother

Naoki Hatakeyama et al. Pediatr Transplant. .

Abstract

PTR is a serious problem in patients being treated for hematologic disorders. Two patients with acute leukemia developed PTR after allogeneic BMT from one HLA-antigen-mismatched mother attributable to HLA antibodies, which could not be detected in their serum before BMT. HLA antibodies, whose specificity resembled that of each patient, were detected in each donor's serum. Each donor had probably been immunized during pregnancy by their partner's HLA antigens expressed by the fetus, consequently, transplanted donor-derived cells provoked HLA antibodies in each recipient early after BMT, and those HLA antibodies induced PTR. If the mothers are selected as donors for their children, they should be tested for the presence of HLA antibodies.

Similar articles

See all similar articles

Cited by 4 articles

Publication types

Feedback