Bacteremia caused by a novel helicobacter species in a 28-year-old man with X-linked agammaglobulinemia

J Clin Microbiol. 2010 Dec;48(12):4672-6. doi: 10.1128/JCM.01350-10. Epub 2010 Sep 29.

Abstract

We report on a case of bacteremia caused by a previously unknown urease-negative Helicobacter strain, IMMIB HP-28/08, isolated from blood cultures of a 28-year-old man with X-linked agammaglobulinemia. The identification of the isolate was based on 16S rRNA gene sequencing. In the phylogenetic tree, the isolate fell into a cluster which included Helicobacter canadensis, Helicobacter equorum, and Helicobacter pullorum. This is the first report of bacteremia caused by this fastidious organism. Further investigations are necessary to determine the potential role of this species as a pathogen of bloodstream infections.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agammaglobulinemia / complications
  • Bacteremia / diagnosis*
  • Bacteremia / microbiology
  • Bacterial Typing Techniques
  • Blood / microbiology
  • Cluster Analysis
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Extremities / pathology
  • Genetic Diseases, X-Linked / complications
  • Helicobacter / enzymology
  • Helicobacter / genetics
  • Helicobacter / isolation & purification*
  • Helicobacter / ultrastructure
  • Helicobacter Infections / diagnosis*
  • Helicobacter Infections / microbiology
  • Humans
  • Male
  • Microscopy, Electron, Transmission
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • Skin / pathology
  • Urease / deficiency

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S
  • Urease

Supplementary concepts

  • Bruton type agammaglobulinemia

Associated data

  • GENBANK/AM992061