Top 10 botanical ingredients in 2010 anti-aging creams

J Cosmet Dermatol. 2010 Sep;9(3):218-25. doi: 10.1111/j.1473-2165.2010.00516.x.


New developments in the realm of skin rejuvenation such as phytotherapy are at an astounding increasing pace in the cosmeceutical market. Yet, many of these products that are classified as cosmeceuticals are tested less vigorously and do not have to be approved by the Food and Drug Administration to establish efficacy and safety. Thus, as clinicians, we must ask the question, "Is there science-based evidence to validate the mechanism of these new treatments?" We assessed the top anti-aging creams currently on the market specifically evaluating their botanical ingredients. Some of the most common botanicals that are hot off the market are: Rosmarinus officinalis, Vitis vinifera (grape seed extract), Citronellol, Limonene, Oenothera biennis (evening primrose), Glycyrrhiza glabra (licorice extract), Aframomum angustifolium seed extract, Diosgenin (wild yam), N6 furfuryladenine (kinetin), and Ergothioneine. Through researching each of these botanical ingredients, we have concluded that randomized controlled trials are still needed in this area, but there is promise in some of these ingredients and science to validate them.

MeSH terms

  • Acyclic Monoterpenes
  • Antioxidants / therapeutic use
  • Cyclohexenes / therapeutic use
  • Diosgenin
  • Ergothioneine / therapeutic use
  • Grape Seed Extract / therapeutic use
  • Humans
  • Kinetin / therapeutic use
  • Limonene
  • Monoterpenes / therapeutic use
  • Oenothera
  • Phytotherapy / methods*
  • Plant Extracts / therapeutic use*
  • Plant Preparations / therapeutic use
  • Rosa
  • Skin Aging / drug effects*
  • Terpenes / therapeutic use
  • Zingiberaceae


  • Acyclic Monoterpenes
  • Antioxidants
  • Cyclohexenes
  • Grape Seed Extract
  • Monoterpenes
  • Plant Extracts
  • Plant Preparations
  • Terpenes
  • Limonene
  • Ergothioneine
  • Diosgenin
  • citronellol
  • Kinetin