Docking proteins

FEBS J. 2010 Nov;277(21):4356-69. doi: 10.1111/j.1742-4658.2010.07865.x. Epub 2010 Sep 30.

Abstract

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • GRB2 Adaptor Protein / metabolism
  • Humans
  • Insulin Receptor Substrate Proteins / metabolism
  • Intracellular Signaling Peptides and Proteins / classification
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological
  • Protein Binding
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction*

Substances

  • GRB2 Adaptor Protein
  • GRB2 protein, human
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Protein-Tyrosine Kinases