Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy

Fertil Steril. 2011 Feb;95(2):762-6. doi: 10.1016/j.fertnstert.2010.08.059.


Objective: To study the effects of reducing hemorrhage by loop ligation of larger myoma pseudocapsules combined with vasopressin on laparoscopic myomectomy (LM).

Design: Prospective controlled clinical trial.

Setting: Sheng Jing Hospital, China Medical University.

Patient(s): A total of 105 women with symptomatic single or multiple larger myomas (diameter 6-18 cm) in need of surgical intervention, who wished to retain their uteri, were randomly divided into three groups in our hospital from January 2006 to January 2008: A) loop ligation combined with vasopressin; B) vasopressin alone; and C) neither loop ligation nor vasopressin. All patients were treated by LM. Each group included 35 cases.

Intervention(s): Loop ligation of larger myoma (6-18 cm) pseudocapsule combined with vasopressin before thoroughly enucleating the myoma.

Main outcome measure(s): Operating time, blood loss, blood transfusion, postoperative stay in hospital, symptom improvement.

Result(s): Average blood loss, postoperative stay in hospital, number of conversions to laparotomy, and need for transfusion because of bleeding during operation in group A were significantly lower than in groups B and C. All patients in group A underwent technically successful laparoscopic operations.

Conclusion(s): Loop ligation of larger myoma pseudocapsules combined with vasopressin is a safe, effective, and promising new method to reduce bleeding during laparoscopic myomectomy and makes the laparoscopic operations with larger myomas easier.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Gynecologic Surgical Procedures / methods*
  • Humans
  • Laparoscopy / methods
  • Leiomyoma / drug therapy*
  • Leiomyoma / pathology
  • Leiomyoma / surgery*
  • Ligation / methods
  • Middle Aged
  • Tumor Burden
  • Uterine Artery / surgery
  • Uterine Neoplasms / drug therapy*
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / surgery
  • Vasoconstrictor Agents / administration & dosage
  • Vasopressins / administration & dosage*
  • Young Adult


  • Vasoconstrictor Agents
  • Vasopressins