Comparison of the effects of long-acting nifedipine CR and diltiazem R in patients with vasospastic angina: Aomori coronary spastic angina study

J Cardiol. 2010 Nov;56(3):354-60. doi: 10.1016/j.jjcc.2010.07.010. Epub 2010 Sep 29.


Objectives: We compared the efficacy of once-daily administration of nifedipine CR 40 mg (N) with that of twice-daily diltiazem R 100mg (D) in patients with vasospastic angina (VSA) registered in 8 cardiovascular institutes in Aomori Prefecture.

Methods and results: VSA was diagnosed by the ischemic ST segment changes during chest pain attacks at rest and/or acetylcholine induction test done during coronary angiography. Thirty-seven patients were randomly allocated to either the N (n=20) or D group (n=17). The number of symptomatic attacks and amount of short-acting nitrate use were examined based on data in diaries written by the patients. There were no significant differences in the baseline characteristics between the two groups. The mean number (median number) of attacks per week was significantly decreased in the N group from 2.56 (2.0) at baseline to 0.41 (0.0) after 4 weeks of treatment, to 0.24 (0.0) after 8 weeks, and to 0.36 (0.0) after 12 weeks (all p<0.05 vs. baseline). It was also decreased in D group from 2.71 (2.0) at baseline to 0.55 (0.0) after 4 weeks, to 0.32 (0.0) after 8 weeks, and to 0.27 (0.0) after 12 weeks (all p<0.05 vs. baseline). The numbers of attacks before and after treatment were comparable between N and D groups. In one patient in each of the N and D groups, the allocated drug was crossed over to the other due to recurrence of the attacks. One patient in each group experienced adverse effects and the drug was changed to the other.

Conclusion: Once-daily administration of nifedipine CR was as effective as twice-daily diltiazem R in the prevention of VSA attacks.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Angina Pectoris / drug therapy*
  • Angina Pectoris / etiology
  • Angina Pectoris / prevention & control
  • Calcium Channel Blockers / administration & dosage*
  • Coronary Vasospasm / complications
  • Coronary Vasospasm / drug therapy*
  • Coronary Vasospasm / prevention & control
  • Cross-Over Studies
  • Delayed-Action Preparations
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Nifedipine / administration & dosage*
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage*


  • Calcium Channel Blockers
  • Delayed-Action Preparations
  • Vasodilator Agents
  • Nifedipine