Transforming growth factor-alpha: an oncodevelopmental growth factor

Cancer Cells. 1990 Dec;2(12):389-97.


Transforming growth factor-alpha (TGF-alpha) is a 50-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately 160 amino acids. The low-molecular-weight TGF-alpha peptide as well as the precursor are biologically active in a number of systems and can function as transforming proteins when overexpressed. TGF-alpha binds to and activates the EGF receptor, and TGF-alpha and the EGF receptor are coexpressed in a number of human and rodent tumors and tumor cell lines--which suggests that TGF-alpha can function as an autocrine or paracrine growth factor. TGF-alpha is transiently expressed in some fetal and adjacent maternal tissues during development and is also expressed in a number of adult tissues; this pattern of expression suggests that the growth factor is involved in several distinct physiological functions.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Differentiation*
  • Cell Division*
  • Cell Transformation, Neoplastic*
  • Epidermal Growth Factor / physiology
  • ErbB Receptors / physiology
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Transforming Growth Factor alpha / physiology*
  • Tumor Cells, Cultured


  • Transforming Growth Factor alpha
  • Epidermal Growth Factor
  • ErbB Receptors