Iron-sulfur world in aerobic and hyperthermoacidophilic archaea Sulfolobus

Archaea. 2010 Sep 19;2010:842639. doi: 10.1155/2010/842639.


The general importance of the Fe-S cluster prosthetic groups in biology is primarily attributable to specific features of iron and sulfur chemistry, and the assembly and interplay of the Fe-S cluster core with the surrounding protein is the key to in-depth understanding of the underlying mechanisms. In the aerobic and thermoacidophilic archaea, zinc-containing ferredoxin is abundant in the cytoplasm, functioning as a key electron carrier, and many Fe-S enzymes are produced to participate in the central metabolic and energetic pathways. De novo formation of intracellular Fe-S clusters does not occur spontaneously but most likely requires the operation of a SufBCD complex of the SUF machinery, which is the only Fe-S cluster biosynthesis system conserved in these archaea. In this paper, a brief introduction to the buildup and maintenance of the intracellular Fe-S world in aerobic and hyperthermoacidophilic crenarchaeotes, mainly Sulfolobus, is given in the biochemical, genetic, and evolutionary context.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aerobiosis
  • Archaeal Proteins / metabolism*
  • Biosynthetic Pathways
  • Ferredoxins / metabolism
  • Iron / chemistry
  • Iron-Sulfur Proteins / metabolism*
  • Models, Molecular
  • Sulfolobus / metabolism*
  • Sulfur / chemistry


  • Archaeal Proteins
  • Ferredoxins
  • Iron-Sulfur Proteins
  • Sulfur
  • Iron