Simultaneous marginal survival estimators when doubly censored data is present

Lifetime Data Anal. 2011 Jul;17(3):347-72. doi: 10.1007/s10985-010-9186-5. Epub 2010 Oct 1.

Abstract

A doubly censoring scheme occurs when the lifetimes T being measured,from a well-known time origin, are exactly observed within a window [L, R] of observational time and are otherwise censored either from above (right-censored observations)or below (left-censored observations). Sample data consists on the pairs (U, δ)where U = min{R, max{T, L}} and δ indicates whether T is exactly observed (δ = 0),right-censored (δ = 1) or left-censored (δ = −1). We are interested in the estimation of the marginal behaviour of the three random variables T, L and R based on the observed pairs (U, δ).We propose new nonparametric simultaneous marginal estimators Ŝ(T) , Ŝ(L) and Ŝ(R) for the survival functions of T, L and R, respectively, by means of an inverse-probability-of-censoring approach. The proposed estimators Ŝ(T) , Ŝ(L) and Ŝ(R) are not computationally intensive, generalize the empirical survival estimator and reduce to the Kaplan-Meier estimator in the absence of left-censored data. Furthermore,Ŝ(T) is equivalent to a self-consistent estimator, is uniformly strongly consistent and asymptotically normal. The method is illustrated with data from a cohort of drug users recruited in a detoxification program in Badalona (Spain). For these data we estimate the survival function for the elapsed time from starting IV-drugs to AIDS diagnosis, as well as the potential follow-up time. A simulation study is discussed to assess the performance of the three survival estimators for moderate sample sizes and different censoring levels.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Anti-HIV Agents / therapeutic use
  • Cohort Studies
  • Computer Simulation
  • Data Interpretation, Statistical*
  • HIV / drug effects
  • HIV / growth & development
  • Humans
  • Kaplan-Meier Estimate*
  • Spain
  • Substance-Related Disorders

Substances

  • Anti-HIV Agents