[Hyperbaric oxygenation in combined treatment of interstitial cystitis]

Urologiia. Jan-Feb 2010;(1):22-4.
[Article in Russian]

Abstract

A total of 116 female patients with painful bladder syndrome/interstitial cystitis aged 32-78 years (mean age 56 +/- 2.4 years) entered the trial. They were divided into two groups according to treatment. Group 1 (n = 54) received 10-day combined conservative treatment consisting of antimicrobial drugs (if urinary infection was diagnosed), angioprotectors, mast cell activity stabilizers and bladder instillation with combined solution. Group 2 included 62 patients whose treatment included complex anti-inflammatory therapy in combination with HBO sessions (7-10 sessions in barochamber OKA-MT, 2.0 +/- 0.2 atm). Subjective (the disease course, pain intensity, 24-h and nocturnal pollakiuria, effective urine volume) and objective (microcirculation in the bladder wall) results were assessed. Dopplerograms revealed venous stagnation. Patients of group 2 had a persistent improvement of microcirculation in bladder mucosa as shown by better blood flow in the veins and arterioles. In group 1 the above improvement was less pronounced. Thus, HBO in combined treatment of interstitial cystitis improves treatment results and promotes long-term remission of the disease.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Combined Modality Therapy
  • Cystitis, Interstitial / drug therapy
  • Cystitis, Interstitial / physiopathology
  • Cystitis, Interstitial / therapy*
  • Female
  • Humans
  • Hyperbaric Oxygenation / methods*
  • Microcirculation / physiology
  • Middle Aged
  • Pain / prevention & control
  • Pain Measurement
  • Treatment Outcome
  • Urinary Bladder / blood supply
  • Urinary Bladder / physiopathology