Regeneration of optic nerve fibers of adult mammals

Dev Growth Differ. 2010 Sep;52(7):567-76. doi: 10.1111/j.1440-169X.2010.01203.x.


The pathway from the retina to the brain in mammals provides a well-defined model system for investigation of not only surviving axotomy but also axonal regeneration of injured neurons. Here I introduce our recent works on axonal regeneration in the optic nerve (OpN) of adult cats. Fibers of retinal ganglion cells (RGCs) extend beyond the crush site of OpN with injections of a macrophage stimulator (oxidized galectin-1) or a Rho kinase (ROCK) inhibitor (Y-39983 or Y-27632) while axonal extension is blocked with injection of saline. Elongation of crushed optic fibers, however, is slowed after 2 weeks. Transplantation of peripheral nerve makes RGCs regenerate their transected axons into a graft but regenerated fibers extend only a few mm in the brain. Effectiveness of combination of the drugs and treatments has to be verified in future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenergic Antagonists / pharmacology
  • Animals
  • Cell Differentiation / drug effects
  • Humans
  • Mammals*
  • Nerve Fibers / drug effects
  • Nerve Fibers / physiology*
  • Nerve Regeneration / drug effects
  • Nerve Regeneration / physiology*
  • Optic Nerve / cytology
  • Optic Nerve / drug effects
  • Optic Nerve / growth & development*


  • Adrenergic Antagonists