Cells of the oligodendroglial lineage, myelination, and remyelination

Biochim Biophys Acta. 2011 Feb;1812(2):184-93. doi: 10.1016/j.bbadis.2010.09.010. Epub 2010 Sep 29.


Myelin is critical in maintaining electrical impulse conduction in the central nervous system. The oligodendrocyte is the cell type responsible for myelin production within this compartment. The mutual supply of trophic support between oligodendrocytes and the underlying axons may indicate why demyelinated axons undergo degeneration more readily; the latter contributes to the neural decline in multiple sclerosis (MS). Myelin repair, termed remyelination, occurs in acute inflammatory lesions in MS and is associated with functional recovery and clinical remittances. Animal models have demonstrated that remyelination is mediated by oligodendrocyte progenitor cells (OPCs) which have responded to chemotactic cues, migrated into the lesion, proliferated, differentiated into mature oligodendrocytes, and ensheathed demyelinated axons. The limited remyelination observed in more chronic MS lesions may reflect intrinsic properties of neural cells or extrinsic deterrents. Therapeutic strategies currently under development include transplantation of exogenous OPCs and promotion of remyelination by endogenous OPCs. All currently approved MS therapies are aimed at dampening the immune response and are not directly targeting neural processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Demyelinating Diseases / pathology
  • Demyelinating Diseases / physiopathology
  • Demyelinating Diseases / therapy
  • Disease Models, Animal
  • Humans
  • Multiple Sclerosis / pathology*
  • Multiple Sclerosis / physiopathology*
  • Multiple Sclerosis / therapy
  • Myelin Sheath / pathology*
  • Myelin Sheath / physiology*
  • Nerve Regeneration / physiology
  • Oligodendroglia / pathology*
  • Oligodendroglia / physiology*
  • Stem Cells / pathology
  • Stem Cells / physiology