Phasic responses in dorsal raphe serotonin neurons to noxious stimuli

Neuroscience. 2010 Dec 29;171(4):1209-15. doi: 10.1016/j.neuroscience.2010.09.058. Epub 2010 Oct 1.


Serotonin is widely implicated in aversive processing. It is not clear, however, whether serotonin neurons encode information about aversive stimuli. We found that, in the dorsal raphe of anesthetized rats, most neurochemically-identified clocklike serotonin neurons were phasically excited by noxious footshocks, whereas most bursting serotonin neurons were inhibited. These results suggest that discrete groups of serotonin neurons differentially code for aversive stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Electroshock / adverse effects
  • Male
  • Neurons / drug effects
  • Neurons / physiology*
  • Physical Stimulation / adverse effects
  • Raphe Nuclei / cytology*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / metabolism*
  • Tryptophan Hydroxylase / metabolism


  • Serotonin
  • Tryptophan Hydroxylase