Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription

Cell Cycle. 2010 Sep 15;9(18):3687-99. doi: 10.4161/cc.9.18.13203. Epub 2010 Sep 1.


RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation
  • Cell Growth Processes
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Gene Expression Profiling
  • Humans
  • Promoter Regions, Genetic
  • Protein Isoforms / metabolism
  • RNA / metabolism
  • RNA Polymerase III / genetics
  • RNA Polymerase III / metabolism*
  • Transcription Factors / metabolism
  • Transcription, Genetic


  • Protein Isoforms
  • Transcription Factors
  • RNA
  • RNA Polymerase III