Feasibility of measuring first pass extraction and flow with rubidium-82 in the kidneys

Am J Physiol Imaging. 1990;5(4):133-40.


A feasibility study has been carried out to evaluate rubidium-82, a potassium analog and generator-produced positron emitter, for measuring renal blood flow using a first pass model. Seven acute dogs were studied with beta probes and positron emission tomography to understand the dynamics of rubidium-82 in the kidneys. Preliminary results show that first pass extraction fraction for rubidium-82 ranged from 80-95% with an average of 89%. During the 150 sec of data collection, approximately 44.5% of the injected dose is excreted in the venous side and 9.75% in the ureter. Flow measurements with rubidium-82 and microspheres correlated well with the average control flow of 5.0 ml/min/gm measured by microspheres and 4.5 ml/min/gm of flow measured by rubidium-82 using the first pass model.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dogs
  • Feasibility Studies
  • Humans
  • Kidney / diagnostic imaging*
  • Renal Circulation / physiology*
  • Rubidium Radioisotopes*
  • Tomography, Emission-Computed*


  • Rubidium Radioisotopes