[Experimental study of cytoprotector effect of succinate-containing drugs on functional activity of liver]

Eksp Klin Farmakol. 2010 Aug;73(8):35-8.
[Article in Russian]

Abstract

Hepatoprotective effect of metabolism correctors has been studied on the model of experimental viral and toxic damage of the liver. Reamberin-based substrate compositions (cytoflavin and remaxol) exhibit antihypoxic effect, antioxidant activity, and cytoprotective action on the background of metabolic effect. Based on these results, the indicated preparations are recommended for clinical trials on acute and chronic viral liver disorders.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Chemical and Drug Induced Liver Injury / drug therapy*
  • Chemical and Drug Induced Liver Injury / metabolism
  • Cytoprotection / drug effects*
  • Hepatitis, Viral, Animal / drug therapy*
  • Hepatitis, Viral, Animal / metabolism
  • Liver / injuries
  • Liver / metabolism*
  • Meglumine / analogs & derivatives*
  • Meglumine / pharmacology
  • Mice
  • Succinates / pharmacology*

Substances

  • Antioxidants
  • Reamberin
  • Remaxol
  • Succinates
  • Meglumine