Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 8, 115

Determinants of Menarche


Determinants of Menarche

Olga Karapanou et al. Reprod Biol Endocrinol.


Menarche is a milestone in a woman's life as it denotes the start of reproductive capacity. Aim of this report is to review the recent developments and the current knowledge in the neuroendocrinology of pubertal onset and the factors, genetic and environmental, that influence menarcheal age. We also review the implications of early or late menarcheal age on a young woman's life.


Figure 1
Figure 1
Stimulatory (arrow) and inhibitory (blind-ended arrow) effectors of GnRH pulsatile secretion. mTOR (mammalian target of rapamycin)

Similar articles

See all similar articles

Cited by 46 PubMed Central articles

See all "Cited by" articles


    1. Heidi DH. Yearbook of Phys Anthropol. 1. Vol. 29. 1986. Menarcheal age in Europe; pp. 81–112. - DOI
    1. Tanner JM. Foetus into Man. 2. Ware: Castlemead Publications; 1989.
    1. Dan TC, Roberts DF. Menarcheal age in University of Warwick young women. J Biol Sci. 1993;25:531–538. - PubMed
    1. Lindgren GW, Degertors IL, Fredrikson A, Loukili A, Mannerfeldt R, Nordin M, Palm K, Petterson M, Sundstrand G, Sylvan E. Menarche 1990 in Stockholm schoolgirls. Acta Paediatr Scand. 1991;80:953–955. doi: 10.1111/j.1651-2227.1991.tb11758.x. - DOI - PubMed
    1. Morris JA, Jordan CL, Breedlove SM. Sexual differentiation of the vertebrate nervous system. Nat Neurosci. 2004;7:1034–1039. doi: 10.1038/nn1325. - DOI - PubMed

LinkOut - more resources