Anaphylactic reaction owing to ondansetron administration in a child with neuroblastoma and safe use of granisetron: a case report

J Pediatr Hematol Oncol. 2010 Nov;32(8):e341-2. doi: 10.1097/MPH.0b013e3181ea214a.


A 1-year-old girl with stage-IV neuroblastoma developed ondansetron hydrochloride anaphylaxis. Safe use of granisetron as an antiemetic after skin prick, oral, and intravenous challenge tests is presented. We present this case to emphasize that ondansetron hydrochloride may cause a serious anaphylactic reaction. In such a case, granisetron may be given to patients as an antiemetic after some provocative tests performed.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Antiemetics / administration & dosage
  • Antiemetics / adverse effects
  • Antineoplastic Agents / adverse effects
  • Brain Neoplasms / drug therapy*
  • Female
  • Granisetron / administration & dosage*
  • Humans
  • Infant
  • Nausea / drug therapy
  • Neuroblastoma / drug therapy*
  • Ondansetron / administration & dosage
  • Ondansetron / adverse effects*
  • Vomiting / drug therapy


  • Antiemetics
  • Antineoplastic Agents
  • Ondansetron
  • Granisetron