Effects of Osmotic-Release Methylphenidate in attention-deficit/hyperactivity Disorder as Measured by Event-Related Potentials

Psychiatry Clin Neurosci. 2010 Oct;64(5):491-8. doi: 10.1111/j.1440-1819.2010.02134.x.

Abstract

Aim: Attention-deficit/hyperactivity disorder (ADHD) is a relatively common central nervous system disorder in school-age children, which may involve a specific disorder in cognition and/or information processing. Event-related potentials (ERP) are commonly used as physiological measures of cognitive function as they are easily measured and non-invasive. Thus, in the present study, we examined the effects of osmotic-release methylphenidate (MPH) (Concerta), a common treatment for childhood attention-deficit/hyperactivity disorder (ADHD), in ADHD children as measured by ERP.

Methods: Ten ADHD children participated after giving consent. Based on the guidelines for evoked potential measurement, mismatch negativity (MMN) and P300 were obtained by auditory odd-ball tasks. We measured both MMN and P300 in the drug-naive condition and after intake of osmotic-release MPH.

Results: The MMN amplitudes after intake of osmotic-release MPH were significantly greater than those in the drug-naive situation at Pz and C4. The P300 amplitudes after intake of osmotic-release MPH were significantly greater than those in the drug-naive situation at Cz and Pz.

Conclusion: MMN and P300 are sensitive tools for measuring the pharmacological effects of osmotic-release MPH in ADHD children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Attention Deficit Disorder with Hyperactivity / physiopathology
  • Central Nervous System Stimulants / administration & dosage*
  • Central Nervous System Stimulants / therapeutic use*
  • Child
  • Delayed-Action Preparations
  • Diagnostic and Statistical Manual of Mental Disorders
  • Electroencephalography
  • Event-Related Potentials, P300 / drug effects*
  • Female
  • Humans
  • Male
  • Methylphenidate / administration & dosage*
  • Methylphenidate / therapeutic use*
  • Wechsler Scales

Substances

  • Central Nervous System Stimulants
  • Delayed-Action Preparations
  • Methylphenidate