Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer

Br J Cancer. 2010 Nov 9;103(10):1479-84. doi: 10.1038/sj.bjc.6605932. Epub 2010 Oct 5.

Abstract

Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

MeSH terms

  • Amino Acids / metabolism
  • Disease Progression
  • Fatty Acids / metabolism
  • Glucose / metabolism
  • Glycogen / metabolism
  • Homeostasis / physiology*
  • Humans
  • Insulin / physiology*
  • Insulin-Like Growth Factor Binding Proteins / physiology
  • Neoplasms / genetics
  • Neoplasms / physiopathology*
  • Neoplasms / therapy
  • Receptor, IGF Type 2 / physiology
  • Signal Transduction
  • Somatomedins / physiology*

Substances

  • Amino Acids
  • Fatty Acids
  • Insulin
  • Insulin-Like Growth Factor Binding Proteins
  • Receptor, IGF Type 2
  • Somatomedins
  • Glycogen
  • Glucose