Post-translational modifications of microtubules

J Cell Sci. 2010 Oct 15;123(Pt 20):3447-55. doi: 10.1242/jcs.063727.


Microtubules--polymers of tubulin--perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cilia / metabolism
  • Humans
  • Microtubules / metabolism*
  • Models, Biological
  • Protein Processing, Post-Translational
  • Tubulin / metabolism


  • Tubulin