The history of p53. A perfect example of the drawbacks of scientific paradigms

EMBO Rep. 2010 Nov;11(11):822-6. doi: 10.1038/embor.2010.159. Epub 2010 Oct 8.


The history of p53 and the various interpretations of its function in cells serves as an example of how scientific paradigms can influence research fields. It also offers some interesting lessons for young scientists in search of a rewarding research topic.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Antigens, Polyomavirus Transforming / metabolism
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Mice
  • Oncogenes
  • Peer Review, Research
  • Phylogeny
  • Protein Binding
  • RNA / metabolism
  • Simian virus 40 / metabolism
  • Tumor Suppressor Protein p53 / history*


  • Antigens, Polyomavirus Transforming
  • Tumor Suppressor Protein p53
  • RNA