Zolendronate associated inflammatory orbital disease

N Z Med J. 2010 Sep 24;123(1323):50-2.


Bisphosphonate infusions are associated with adverse events in approximately a third of patients. Ocular complications are rare and even more so, inflammatory orbital disease. Bisphosphonate-induced orbital inflammation is not a well recognised complication and there have been only a few published case reports of this. We present a case of orbital inflammatory disease associated with zolendronate infusion.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Bone Density Conservation Agents / adverse effects*
  • Diabetic Foot / drug therapy*
  • Diagnosis, Differential
  • Diphosphonates / adverse effects*
  • Humans
  • Imidazoles / adverse effects*
  • Male
  • Middle Aged
  • Orbital Diseases / chemically induced*
  • Orbital Diseases / diagnosis
  • Zoledronic Acid


  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid