Abstract
Hydraphile synthetic ion channels were found to enhance the cytotoxicity to E. coli and B. subtilis of erythromycin, kanamycin, rifampicin, and tetracycline when co-administered with the antibiotic at sublethal concentrations of channel.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Bacillus subtilis / drug effects
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Erythromycin / chemistry
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Erythromycin / pharmacology
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Escherichia coli / drug effects
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Ion Channels / metabolism*
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Kanamycin / chemistry
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Kanamycin / pharmacology
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Microbial Sensitivity Tests
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Rifampin / chemistry
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Rifampin / pharmacology
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Tetracycline / chemistry
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Tetracycline / pharmacology
Substances
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Anti-Bacterial Agents
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Ion Channels
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Kanamycin
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Erythromycin
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Tetracycline
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Rifampin