Lipidomics era: accomplishments and challenges

Mass Spectrom Rev. Nov-Dec 2010;29(6):877-929. doi: 10.1002/mas.20294.


Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to pose a challenge for lipid analysis. Here we review the current state of the art in lipidomics research and discuss the challenges facing this field. The latest technological developments in mass spectrometry, the role of bioinformatics, and the applications of lipidomics in lipid metabolism and cellular physiology and pathology are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Membrane / ultrastructure
  • Cell Physiological Phenomena
  • Computational Biology
  • Fats, Unsaturated / chemistry
  • Homeostasis
  • Humans
  • Hydrocarbons / chemistry
  • Lipid Metabolism / genetics
  • Lipid Metabolism / physiology*
  • Lipids / chemistry*
  • Lipids / physiology
  • Mass Spectrometry / instrumentation
  • Metabolomics / methods*
  • Molecular Conformation
  • Signal Transduction
  • Tandem Mass Spectrometry


  • Fats, Unsaturated
  • Hydrocarbons
  • Lipids