Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats

West Indian Med J. 2010 Jan;59(1):3-6.


Objective: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken.

Materials and methods: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study.

Results: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg.

Conclusion: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Asparagus Plant*
  • Diuretics / pharmacology
  • Diuretics / toxicity*
  • Furosemide / pharmacology
  • Furosemide / toxicity
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Extracts / toxicity*
  • Plant Roots / toxicity*
  • Rats
  • Rats, Wistar


  • Diuretics
  • Plant Extracts
  • Furosemide