Composition, assembly, and maintenance of excitable membrane domains in myelinated axons

Semin Cell Dev Biol. 2011 Apr;22(2):178-84. doi: 10.1016/j.semcdb.2010.09.010. Epub 2010 Oct 12.


Neurons have many specialized membrane domains with diverse functions responsible for receiving, integrating, and transmitting electrical signals between cells in a circuit. Both the locations and protein compositions of these domains defines their functions. In axons, two of the most important membrane domains are the axon initial segment and the nodes of Ranvier. Proper assembly and maintenance of these domains is necessary for action potential generation and propagation, and the overall function of the neuron.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Cell Adhesion Molecules / metabolism
  • Extracellular Matrix / metabolism
  • Humans
  • Ion Channels / metabolism
  • Myelin Sheath / metabolism*
  • Neuronal Plasticity


  • Cell Adhesion Molecules
  • Ion Channels