Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease

Neurosci Lett. 2011 Jan 3;487(1):70-2. doi: 10.1016/j.neulet.2010.09.076. Epub 2010 Oct 7.

Abstract

The present work explored the anti-neuroinflammation effects of Ginseng Rb1 in a rat model of Alzheimer disease produced by ventricle injection of Aβ1-42. Aβ1-42 injection induces loss of learning and memory behavior of rats in Morris water maze, which could be reversed with Rb1 treatment. Further, Rb1 reversed the changes in several direct or indirect neuroinflammation markers in the hippocampus, suggesting that this could be a potential underlying mechanism and a way to develop anti-aging drugs.

MeSH terms

  • Alzheimer Disease / chemically induced
  • Alzheimer Disease / complications*
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / adverse effects
  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Brain / drug effects
  • Brain / metabolism
  • Brain / pathology
  • Disease Models, Animal
  • Encephalitis / drug therapy*
  • Encephalitis / etiology*
  • Ginsenosides / therapeutic use*
  • Male
  • Maze Learning / drug effects
  • Peptide Fragments / adverse effects
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents
  • Ginsenosides
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • ginsenoside Rb1