Tissue-specific differences in mitochondrial activity and biogenesis

Mitochondrion. 2011 Jan;11(1):207-13. doi: 10.1016/j.mito.2010.09.011. Epub 2010 Oct 7.


Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number, function, protein composition and morphology. The OXPHOS system biogenesis requires the coordinated expression of both mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be regulated at different levels (replication, transcription, translation and post-translational levels) to contribute to the final observed OXPHOS activities. By analyzing five mammalian tissues, we evaluated the differences in the cellular amount of mtDNA and its correlation with the final observed mitochondrial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Citrate (si)-Synthase
  • DNA, Mitochondrial / analysis*
  • DNA, Mitochondrial / genetics
  • DNA, Mitochondrial / metabolism
  • Electron Transport Complex IV
  • Female
  • Gene Dosage*
  • Gene Expression Regulation*
  • Male
  • Mitochondria / genetics
  • Mitochondria / metabolism*
  • Muscle, Skeletal / metabolism
  • Organ Specificity*
  • Oxidative Phosphorylation
  • Rats
  • Rats, Wistar
  • Transcription, Genetic


  • DNA, Mitochondrial
  • Electron Transport Complex IV
  • Citrate (si)-Synthase