MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

Mitochondrion. 2011 Mar;11(2):351-6. doi: 10.1016/j.mito.2010.09.013. Epub 2010 Oct 7.


MitoTool, a web-based bioinformatics platform, is designed for deciphering human mitochondrial DNA (mtDNA) data in batch mode. The platform has advantages in (i) parsing diverse types of mtDNA data; (ii) automatically classifying haplogroup according to mtDNA sequences or variants; (iii) discovering possibly missing variants of the samples with claimed haplogroups status; (iv) estimating the evolutionary conservation index, protein coding effect and potential pathogenicity of certain substitutions; (v) performing statistical analysis for haplogroup distribution frequency between case and control groups. Furthermore, it offers an integrated database for retrieving five types of mitochondrion-related information. The MitoTool is freely accessed at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Primers
  • DNA, Mitochondrial / genetics*
  • Humans
  • Internet*


  • DNA Primers
  • DNA, Mitochondrial