Functions of B56-containing PP2As in Major Developmental and Cancer Signaling Pathways

Life Sci. 2010 Dec 18;87(23-26):659-66. doi: 10.1016/j.lfs.2010.10.003. Epub 2010 Oct 8.

Abstract

Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Protein Phosphatase 2 / metabolism*
  • Protein Subunits
  • Signal Transduction*
  • Substrate Specificity

Substances

  • Protein Subunits
  • Protein Phosphatase 2