The roles of thiol oxidoreductases in yeast replicative aging

Mech Ageing Dev. 2010 Nov-Dec;131(11-12):692-9. doi: 10.1016/j.mad.2010.09.006. Epub 2010 Oct 8.


Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / biosynthesis
  • Cell Cycle Proteins / metabolism
  • Cellular Senescence*
  • Methyltransferases / genetics
  • Methyltransferases / physiology*
  • Mutation
  • Protein Folding
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Thioredoxins / metabolism
  • Water / pharmacology


  • Cell Cycle Proteins
  • MEC3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Water
  • Thioredoxins
  • Adenosine Triphosphate
  • Methyltransferases
  • thiol S-methyltransferase