A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content

Nutr Res. 2010 Sep;30(9):632-43. doi: 10.1016/j.nutres.2010.09.003.


The present study tested the hypothesis that a saturated fatty acid (SFA)-rich diet is more obesogenic than diets with lower SFA content. In 8 female Sprague-Dawley rats fed a low-SFA canola or a moderate-SFA lard-rich diets at 67% of energy for 26 days, body weight gain, final body weight, obesity index, and food and energy intake were comparable. Twenty-nine rats were fed canola or high-SFA butter-rich diets (67% of energy) or chow for 50 days; then high-fat feeding was followed by ad libitum low-fat feeding (27% of energy) for 28 days and by a food-restricted low-fat diet for 32 days. High-fat feeding resulted in a greater body weight gain (P < .04), final body weight (P < .04), and energy intake (P < .008) in butter-fed rats than in canola- and chow-fed controls, after 26 or 50 days. Ad libitum canola and butter low-fat diets or chow feeding resulted in similar weight change, whereas food-restricted low-fat diets led to comparable weight loss and final weight. Canola-fed animals adjusted their intake based on diet energy density, whereas lard and butter-fed animals failed to do so. Abdominal fat (P = .012) and plasma leptin (P = .005) were higher in chow-fed controls than in canola-fed rats, but comparable with those of butter-fed rats. Prone and resistant phenotypes were detected with high-fat feeding. In conclusion, only feeding the high-SFA butter-rich diet led to obesity development and failure to adjust intake based on the energy density and preserving body fat even after weight loss. The high availability of SFA-rich foods in today's obesogenic environment could contribute to develop and maintain obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Fat / drug effects*
  • Animals
  • Appetite Regulation / drug effects*
  • Body Weight / drug effects
  • Butter / adverse effects
  • Diet, Fat-Restricted
  • Diet, Reducing
  • Dietary Fats / administration & dosage
  • Dietary Fats / adverse effects*
  • Energy Intake / drug effects*
  • Fatty Acids / administration & dosage
  • Fatty Acids / adverse effects*
  • Fatty Acids, Monounsaturated / pharmacology
  • Female
  • Food Deprivation
  • Leptin / blood
  • Obesity / blood
  • Obesity / etiology*
  • Obesity / physiopathology
  • Rapeseed Oil
  • Rats
  • Rats, Sprague-Dawley
  • Weight Gain / drug effects*
  • Weight Loss / drug effects


  • Dietary Fats
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Leptin
  • Rapeseed Oil
  • Butter