Synthesis and Molecular Modelling Studies of Prenylated Pyrazolines as MAO-B Inhibitors

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6479-82. doi: 10.1016/j.bmcl.2010.09.061. Epub 2010 Sep 17.

Abstract

A series of N-substituted-3-[(2'-hydroxy-4'-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Inhibitory Concentration 50
  • Models, Molecular
  • Molecular Structure
  • Monoamine Oxidase / drug effects*
  • Monoamine Oxidase Inhibitors / chemical synthesis*
  • Monoamine Oxidase Inhibitors / chemistry
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Prenylation*
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Structure-Activity Relationship

Substances

  • Monoamine Oxidase Inhibitors
  • Pyrazoles
  • Monoamine Oxidase