Spectral-domain OCT peripapillary retinal nerve fibre layer thickness measurements in patients with Stargardt disease

Br J Ophthalmol. 2011 May;95(5):689-93. doi: 10.1136/bjo.2010.189720. Epub 2010 Oct 8.

Abstract

Aims: To evaluate the presence of peripapillary retinal nerve fibre layer (RNFL) defects in patients with Stargardt disease by using spectral-domain optical coherence tomography (SD-OCT).

Methods: Fifty-two eyes of 27 patients with Stargardt disease underwent peripapillary RNFL thickness measurements using SD-OCT.

Results: Twenty-seven patients with Stargardt disease were enrolled. Their mean (±SD) age was 38.3 (14.7) years. Fourteen patients (51.9%) showed a thinning of the peripapillary RNFL in one or more quadrants in at least one eye, and four patients (14.8%) in both eyes. Five patients (18.5%) showed a thickening of the peripapillary RNFL in at least one eye, and four patients (14.8%) in both eyes.

Conclusion: This study demonstrated the presence of defects in the peripapillary RNFL thickness in patients with Stargardt disease by using SD-OCT. It would be clinically prudent that Stargardt patients considered for various treatment options be considered for RNFL thickness measurements.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Macula Lutea / pathology*
  • Macular Degeneration / congenital
  • Macular Degeneration / pathology
  • Male
  • Middle Aged
  • Nerve Fibers / pathology*
  • Prospective Studies
  • Retina / pathology*
  • Stargardt Disease
  • Tomography, Optical Coherence
  • Visual Acuity / physiology*
  • Young Adult

Supplementary concepts

  • Stargardt disease 1