What is the advantage of a transient precursor in autophagosome biogenesis?

Autophagy. 2011 Jan;7(1):118-22. doi: 10.1083/jcb.200803137. Epub 2011 Jan 1.

Abstract

We have recently proposed that some autophagosomes are formed within omegasomes, membrane sites connected to the endoplasmic reticulum and enriched in phosphatidylinositol 3-phosphate. In order to understand if there is any biological advantage to having such a precursor in autophagosome biogenesis, we generated a simple computer program that simulates omegasome and autophagosome formation under a variety of conditions. We concluded from running this simulation that having a transient precursor permits a bigger dynamic range of the autophagic response and allows a more efficient approach to steady state after autophagy stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Computer Simulation
  • Green Fluorescent Proteins / metabolism
  • Humans
  • Imaging, Three-Dimensional
  • Microtubule-Associated Proteins / metabolism
  • Phagosomes / metabolism*
  • Time Factors

Substances

  • Microtubule-Associated Proteins
  • Green Fluorescent Proteins