APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity

Cell Cycle. 2010 Oct 1;9(19):3904-12. doi: 10.4161/cc.9.19.13585. Epub 2010 Oct 11.


Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology*
  • G1 Phase / physiology
  • Genome*
  • Humans
  • Mitosis / physiology
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction
  • Ubiquitin-Protein Ligase Complexes / genetics
  • Ubiquitin-Protein Ligase Complexes / metabolism*


  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome