Vaccines and immunotherapeutics for the treatment of malignant disease

Clin Dev Immunol. 2010;2010:697158. doi: 10.1155/2010/697158. Epub 2010 Sep 26.


The employment of the immune system to treat malignant disease represents an active area of biomedical research. The specificity of the immune response and potential for establishing long-term tumor immunity compels researchers to continue investigations into immunotherapeutic approaches for cancer. A number of immunotherapeutic strategies have arisen for the treatment of malignant disease, including various vaccination schemes, cytokine therapy, adoptive cellular therapy, and monoclonal antibody therapy. This paper describes each of these strategies and discusses some of the associated successes and limitations. Emphasis is placed on the integration of techniques to promote optimal scenarios for eliminating cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / immunology
  • Antigens, Neoplasm / administration & dosage
  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / genetics
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Cytokines / administration & dosage
  • Cytokines / immunology
  • Dendritic Cells / immunology
  • Dogs
  • Humans
  • Immunotherapy / methods*
  • Mice
  • Neoplasms / immunology*
  • Neoplasms / therapy*


  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Cancer Vaccines
  • Cytokines