AV119, a Natural Sugar From Avocado Gratissima, Modulates the LPS-induced Proinflammatory Response in Human Keratinocytes

Inflammation. 2011 Dec;34(6):568-75. doi: 10.1007/s10753-010-9264-6.

Abstract

Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of Malassezia furfur, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrates / immunology*
  • Cytokines / analysis
  • Heat-Shock Proteins / analysis
  • Humans
  • Immunity, Innate / drug effects
  • Inflammation / drug therapy*
  • Keratinocytes / drug effects
  • Keratinocytes / immunology
  • Keratinocytes / pathology*
  • Lipopolysaccharides / pharmacology
  • NF-kappa B / immunology
  • Persea / chemistry*
  • Persea / immunology
  • Sugars
  • Toll-Like Receptor 4 / immunology

Substances

  • AV119
  • Carbohydrates
  • Cytokines
  • Heat-Shock Proteins
  • Lipopolysaccharides
  • NF-kappa B
  • Sugars
  • Toll-Like Receptor 4