Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;39(5):454-7.

[Effects of Hydrogen Gas Inhalation on Serum High Mobility Group Box 1 Levels in Severe Septic Mice]

[Article in Chinese]
Affiliations
  • PMID: 20936717

[Effects of Hydrogen Gas Inhalation on Serum High Mobility Group Box 1 Levels in Severe Septic Mice]

[Article in Chinese]
Ke-Liang Xie et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract

Objective: To investigate the effect of hydrogen gas inhalation on survival rate and serum high mobility group box 1 (HMGB1) levels in severe septic mice.

Methods: Severe sepsis was induced by cecal ligation and puncture (CLP) operation in mice.A total of 248 mice were randomly divided into four groups: sham operation group (sham), sham operation with hydrogen gas inhalation group (sham+H2), severe CLP group (severe CLP) and severe CLP with hydrogen gas inhalation group (severe CLP+H2). Hydrogen gas inhalation was given for 1 h at 1st and 6th h after CLP or sham operation, respectively. The survival rates and serum HMGB1 levels of all groups at different time points were measured.

Result: The 7-d survival rates of severe CLP mice was 0 % (Compared with Sham group, P <0.05), and the serum HMBG1 levels from h2 to h32 after CLP operation were significantly increased in severe CLP mice (Compared with Sham group, P <0.05). Hydrogen gas treatment increased the 7-d survival rate of severe CLP mice to 60 % (Compared with severe sepsis group, P <0.05) and significantly reduced the serum HMGB1 levels at different time points (Compared with severe sepsis group, P <0.05).

Conclusion: Hydrogen gas inhalation can decrease the serum HMGB1 levels and increase the survival rate of rats with severe sepsis.

Similar articles

See all similar articles

Cited by 1 article

Publication types

Feedback