Association analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population

Wei Liu; Na Zhao; Jidong Xiong; Mei Shi; Jian Hu

doi:10.1016/j.psychres.2010.08.030

Association analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population

Psychiatry Res. 2011 Jun 30;188(1):170-2. doi: 10.1016/j.psychres.2010.08.030. Epub 2010 Oct 9.

Authors

Wei Liu¹, Na Zhao, Jidong Xiong, Mei Shi, Jian Hu

Affiliation

¹ Department of Psychiatry and Psychology, Harbin Medical University, 150001, Harbin, China. liuwei8672684@hotmail.com

PMID: 20937529
DOI: 10.1016/j.psychres.2010.08.030

Abstract

Serotonin and catecholamine system studies provide increasing evidence for the importance of genetic factors in obsessive-compulsive disorder (OCD); we found that genetic linkage disequilibrium with OCD existed in the 5-HT2A-receptor promoter polymorphism -1438G/A. The results of our research strongly suggested that the -1438G/A promoter polymorphism plays a role in the psychopathology of OCD.

MeSH terms

Catecholamines / genetics*
China / epidemiology
Female
Genetic Predisposition to Disease*
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Male
Obsessive-Compulsive Disorder / genetics*
Polymorphism, Genetic / genetics*
Serotonin / genetics*

Substances

Catecholamines
Serotonin