Retrospective study of canine nasal tumor treated with hypofractionated radiotherapy

J Vet Med Sci. 2011 Feb;73(2):193-7. doi: 10.1292/jvms.10-0194. Epub 2010 Oct 5.


The object of this study was to evaluate hypofractionated multiportal field and two-portion (rostral and caudal portions divided by the eyelid) radiation therapy for canine nasal tumors. Sixty-three dogs underwent multiportal hypofractionated radiation therapy. The radiation field was divided into rostral and caudal portions by the eyelid. Treatments were performed four times for 57 dogs. The median irradiation dose/fraction was 8 Gy (range, 5-10 Gy); the median total dose was 32 Gy (10-40 Gy). Improvement of clinical symptoms was achieved in 53 (84.1%) of 63 cases. Median survival time was 197 days (range, 2-1,080 days). Median survival times with and without destruction of the cribriform plate before radiotherapy were 163 and 219 days, respectively. There was no significant difference between them. No other factors were related to survival according to a univariate analysis. All radiation side effects, except one, were grade I according to the VRTOG classification. It was not necessary to treat any dogs for skin side effects. One dog (1.6%) developed an oronasal fistula 1 year after completion of radiation therapy. This radiation protocol may be useful in reducing radiation side effects in dogs with cribriform plate destruction.

MeSH terms

  • Animals
  • Dog Diseases / radiotherapy*
  • Dogs
  • Dose Fractionation, Radiation
  • Female
  • Kaplan-Meier Estimate
  • Male
  • Nose Neoplasms / radiotherapy*
  • Nose Neoplasms / veterinary*
  • Retrospective Studies