[Effects of Klamath Algae extract on psychological disorders and depression in menopausal women: a pilot study]

Minerva Ginecol. 2010 Oct;62(5):381-8.
[Article in Italian]


Aim: Menopause transition is able to induce a significant change in the quality of life of women and a growing demand for alternative treatments to hormonal therapy of the psychological and somatic/vasomotor symptoms related to menopausal transition has been observed in these last years. In this study we aimed to investigate the effect of a two-month supplementation period with the Klamath algae extract Klamin® on the general and psychological well-being of a group of 30 menopausal women, free from any hormonal therapy.

Methods: Patients were randomly subdivided in 2 groups (15 patients each) and each of them was treated with Algae Klamath extract (Klamin®, Nutrigea, Urbino, Italy) (1600 g/day) or with placebo (vanilla tablets) for 8 weeks. Patients were evaluated both for the hormonal and psychological profiles (Symptom Rating Scale - Italian version [SRT] and Zung Self-Rating Scale) before and after the treatment interval.

Results: Both groups of patients were similar in baseline conditions but significant changes were observed after the treatment interval in the group administered with Algae Klamath extracts. Though no hormonal changes occurred after the treatment interval in both groups, only patients under Klamin administration showed both SRT and Zung scales significantly improved, thus reporting a consistent change in their quality of life, for mood, anxiety and depressive attitude.

Conclusion: Since the Klamath extract did not show steroid-like effects on the hormonal parameters, it could be proposed as valid integration for those women seeking for alternative treatment to hormonal therapy so that to overcome many of the menopausal symptoms.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Complex Mixtures / therapeutic use*
  • Cyanobacteria*
  • Depression / drug therapy*
  • Female
  • Humans
  • Menopause*
  • Middle Aged
  • Mood Disorders / drug therapy*
  • Phytotherapy*
  • Pilot Projects


  • Complex Mixtures