mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

World J Gastroenterol. 2010 Oct 14;16(38):4846-53. doi: 10.3748/wjg.v16.i38.4846.

Abstract

Aim: To investigate whether microsomal prostaglandin E synthase-1 (mPGES-1) expression in hepatocellular carcinoma (HCC) and in non-cancerous liver affects HCC prognosis after hepatectomy.

Methods: The relationship between patient clinical profiles, tumor factors, surgical determinants, and mPGES-1 expression and the recurrence-free survival rate were examined in 64 patients who underwent curative hepatectomy between March 2003 and December 2006.

Results: The scores for mPGES-1 expression were higher in well differentiated and moderately differentiated HCC tissues than in poorly differentiated HCC tissues (well differentiated, 5.1 ± 2.7; moderately differentiated, 5.1 ± 1.7; poorly differentiated, 3.0 ± 1.8). In non-cancerous liver tissues, the mPGES-1 levels were higher in injured liver tissues than in normal tissues. Cirrhotic livers had higher mPGES-1 levels than livers with chronic hepatitis (normal livers, 3.3 ± 0.7; chronic hepatitic livers, 5.4 ± 1.9; cirrhotic livers, 6.4 ± 1.6). A univariate analysis revealed that the recurrence-free survival rate was significantly lower in patients with vascular invasion, a higher mPGES-1 level in non-cancerous liver tissue, a larger tumor diameter (≥ 5 cm), and a lower serum albumin level (≤ 3.7 g/dL). The mPGES-1 expression in HCC tissues did not correlate well with postoperative recurrence. A multivariate analysis demonstrated that the presence of vascular invasion and higher mPGES-1 levels were statistically significant independent predictors for early postoperative recurrence of HCC.

Conclusion: Increased mPGES-1 expression in non-cancerous liver tissues is closely associated with the early recurrence of HCC after curative resection.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular* / pathology
  • Carcinoma, Hepatocellular* / prevention & control
  • Carcinoma, Hepatocellular* / surgery
  • Disease-Free Survival
  • Female
  • Hepatectomy
  • Humans
  • Intramolecular Oxidoreductases / metabolism*
  • Liver / metabolism*
  • Liver / pathology
  • Liver Neoplasms* / pathology
  • Liver Neoplasms* / prevention & control
  • Liver Neoplasms* / surgery
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local* / metabolism
  • Neoplasm Recurrence, Local* / pathology
  • Neoplasm Recurrence, Local* / prevention & control
  • Prognosis
  • Prostaglandin-E Synthases

Substances

  • Intramolecular Oxidoreductases
  • PTGES protein, human
  • Prostaglandin-E Synthases