Organosulfur compounds and cardiovascular disease

Mol Aspects Med. 2010 Dec;31(6):540-5. doi: 10.1016/j.mam.2010.09.009. Epub 2010 Oct 19.


Epidemiological studies have shown an inverse relationship between consumption of fruits and vegetables and the risk of cardiovascular disease. Phytochemicals are non-nutritional chemical compounds found in small quantities in fruits and vegetables with known health benefits. Among them, organosulfides are present mainly in garlic and onion characterized by their antioxidant and anti-inflammatory properties, and isothiocyanates in cruciferous vegetables have anticarcinogenic effects in experimental models. In this review, we are focusing on the main biological studies regarding the beneficial effect of organosulfur compounds on their protection against cardiovascular disease.

MeSH terms

  • Animals
  • Cardiovascular Diseases / prevention & control*
  • Diet
  • Fruit / chemistry
  • Humans
  • Isothiocyanates / pharmacology
  • Models, Animal
  • Sulfoxides
  • Sulfur Compounds / pharmacology*
  • Thiocyanates / pharmacology
  • Vegetables / chemistry


  • Isothiocyanates
  • Sulfoxides
  • Sulfur Compounds
  • Thiocyanates
  • sulforaphane