New anti-HBV caryophyllane-type sesquiterpenoids from Euphorbia humifusa Willd

Ying Tian; Li-Min Sun; Bin Li; Xi-Qiao Liu; Jun-Xing Dong

doi:10.1016/j.fitote.2010.10.005

New anti-HBV caryophyllane-type sesquiterpenoids from Euphorbia humifusa Willd

Fitoterapia. 2011 Mar;82(2):251-4. doi: 10.1016/j.fitote.2010.10.005. Epub 2010 Oct 16.

Authors

Ying Tian¹, Li-Min Sun, Bin Li, Xi-Qiao Liu, Jun-Xing Dong

Affiliation

¹ Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, PR China.

PMID: 20940034
DOI: 10.1016/j.fitote.2010.10.005

Abstract

Activity-guided fractionation of Euphorbia humifusa for anti-HBV activity led to the isolation of two novel sesquiterpenoids, named humifusane A (1) and humifusane B (2). Their structures were elucidated by spectral data to show that they have a caryophyllane-type precursor structure. The two new sesquiterpenoids showed anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / pharmacology*
Antiviral Agents / therapeutic use
Euphorbia / chemistry*
Hep G2 Cells
Hepatitis B / drug therapy*
Hepatitis B / metabolism
Hepatitis B Surface Antigens / metabolism*
Hepatitis B virus / drug effects*
Hepatitis B virus / pathogenicity
Humans
Molecular Structure
Phytotherapy*
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Sesquiterpenes / therapeutic use

Substances

Antiviral Agents
Hepatitis B Surface Antigens
Sesquiterpenes
humifusane A
humifusane B